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Serum or plasma substance concentration (e.g., protein) by immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of a specific protein or substance in your blood, typically using a sensitive antibody-based test.

Quick summary

["Your blood protein levels can help diagnose or monitor certain health conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
5353-8
Short code
ENA SS-B Ab Ser Ql IA
Synonyms
ENA SS-B Ab Ser Ql IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

This test detects the presence and concentration of a particular protein or substance in your serum or plasma. The method involves using antibodies to bind specifically to the target analyte, allowing for highly sensitive detection. The result is expressed as a concentration value, often in milligrams per deciliter (mg/dL) or another relevant unit, depending on the analyte.

Why It’s Done

Healthcare providers may order this test to screen for, diagnose, or monitor conditions such as infections, inflammatory diseases, kidney function, or certain genetic disorders. It can also help assess protein loss in urine or other body fluids.

Common Uses

For example, this test might be used to check for abnormal protein levels in conditions like multiple myeloma (a cancer of plasma cells), acute-phase reactants in infections or inflammation, or specific carrier proteins in metabolic disorders.

How the Test Works

Blood is drawn and separated into serum or plasma. The sample is then analyzed using an immunoassay, which detects the target protein or substance by measuring its interaction with antibodies. The test is highly specific and sensitive, often automated for quick and accurate results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Frequently asked questions

What might cause abnormal results?
Abnormal protein levels can result from a variety of conditions, including infections (e.g., bacterial or viral), autoimmune diseases (e.g., rheumatoid arthritis), kidney disease, liver disease, or certain cancers. High levels may indicate inflammation or overproduction of the protein, while low levels could suggest loss in urine, liver dysfunction, or genetic disorders.
How often should I get this test?
The frequency depends on your medical condition and why the test was ordered. Some tests are done once, while others may be repeated periodically (e.g., monthly, quarterly) to monitor progression or treatment response. Always follow your healthcare provider’s instructions.
What do my results mean?
Your results will be compared to a reference range provided by your lab. If your level is outside the expected range, your doctor will discuss potential causes and next steps, such as further testing or treatment adjustments.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy