Serum or Plasma Alpha-1 Antitrypsin (A1AT) Concentration

Why This Test May Be Ordered

Your healthcare provider may recommend this test if you have symptoms of lung conditions like chronic obstructive pulmonary disease (COPD), emphysema, or bronchiectasis, or if you have a family history of lung disease. It may also be checked in cases of unexplained liver issues or if you have a genetic predisposition to Alpha-1 Antitrypsin deficiency.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test if it involves a blood draw, but this depends on your healthcare provider’s instructions. Bring any medications you’re currently taking to your appointment.

How the Test Is Performed

A healthcare professional will draw blood from a vein in your arm using a small needle. The blood sample is then sent to a lab for analysis using an immunoassay method to measure Alpha-1 Antitrypsin levels.

What the Results Mean

Results are compared to standard reference ranges to determine if your levels are within normal limits, low, or high. Low levels may indicate Alpha-1 Antitrypsin deficiency, which can increase the risk of lung disease or liver problems. High levels may be seen in certain liver conditions or during pregnancy.