: Endomysium IgA Antibody, Serum
: This test looks for IgA antibodies that target the endomysium, a connective tissue structure, and is used mainly to help evaluate celiac disease.
[": A positive endomysial IgA antibody result supports further evaluation for celiac disease, but results must be interpreted with your clinical history and other tests."]
Key facts at a glance
- LOINC
- 10362-2
- Short code
- Endomysium IgA Ser Ql
- Synonyms
- Endomysium IgA Ser Ql
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
: What This Test Measures
: The test detects IgA-class antibodies that bind to endomysium, part of the supportive tissue around smooth muscle. These antibodies are strongly associated with celiac disease, an immune reaction to gluten.
: Why It Is Ordered
: Your clinician may order this test when celiac disease is suspected, based on symptoms such as diarrhea, bloating, weight loss, fatigue, or iron deficiency, or because of a family history or related conditions.
: How the Sample Is Collected
: A routine blood sample is drawn from a vein and the serum is separated for testing. No special preparation is usually required unless your care team gives other instructions.
: What Results Mean
: A positive result suggests an immune response consistent with celiac disease and usually prompts confirmation with additional testing or specialist evaluation. A negative result makes celiac disease less likely but does not rule it out. Results can be affected by IgA deficiency, so total IgA may be checked.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
: Endomysial IgA antibodies are highly specific for celiac disease and are often used alongside tissue transglutaminase antibody testing. Because IgA deficiency can cause false-negative results, clinicians frequently measure total IgA. A definite diagnosis generally requires correlation with symptoms, genetic and serologic testing, and sometimes small-bowel biopsy. This test should not be used alone to start or stop a gluten-free diet.
Short name
: Endomysial IgA
Frequently asked questions
: Do I need to eat gluten before this test?
: Does a positive result always mean I have celiac disease?
: Can this test be negative if I have celiac disease?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy