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Endomysial Antibody (IgG) - Serology

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies against endomysium, a protein found in the muscles of the small intestine. It is commonly used to help diagnose celiac disease, an autoimmune condition where the immune system attacks the lining of the small intestine.

Quick summary

["This test helps identify celiac disease by detecting specific antibodies linked to intestinal damage."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
45136-9
Short code
Endomysium IgG Ser-aCnc
Synonyms
Endomysium IgG Ser-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may recommend this test if you have symptoms like persistent diarrhea, stomach pain, weight loss, or fatigue, especially if you’ve been exposed to gluten or have a family history of celiac disease. It may also be used as part of a screening or confirmation process for suspected celiac disease.

What Does a Positive Result Mean?

A positive result strongly suggests celiac disease, as it indicates the presence of antibodies that attack the small intestine’s lining. However, false positives can occur, so further testing (like a biopsy of the intestine) may be needed to confirm the diagnosis.

What Does a Negative Result Mean?

A negative result means the test did not detect these specific antibodies, which could mean celiac disease is not present. However, it’s important to note that some people with celiac disease may not test positive initially, so follow-up testing or other diagnostic methods may still be required.

What to Expect During the Test

This test involves drawing blood from a vein in your arm. The blood sample is sent to a lab for analysis. It typically takes a few days to receive results, depending on lab processing times.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgG Endomysial Antibody

Frequently asked questions

What are the possible side effects or risks of this test?
The most common side effect is mild bruising or soreness at the injection site. Rarely, there may be a slight reaction to the needle. There are no significant risks associated with this blood test.
How often should I get this test if I have celiac disease?
If you have celiac disease, your doctor may recommend regular monitoring, especially if you’re on a gluten-free diet. However, antibody levels can fluctuate, so follow-up testing is usually based on symptoms or clinical judgment rather than a fixed schedule.
Can I eat gluten before this test?
Yes, you can eat your normal diet before this test. Antibody levels are not affected by gluten intake at the time of testing, but if you suspect celiac disease, it’s important to discuss your diet with your healthcare provider before starting any treatment.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy