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Endomysial Antibody (IgG) – Serology Test

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies against endomysium, a protein found in the muscle fibers of the stomach lining. It is commonly used to help diagnose celiac disease, an autoimmune condition triggered by gluten.

Quick summary

["Helps detect celiac disease by checking for specific antibodies linked to gluten sensitivity."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
39554-1
Short code
Endomysium IgG Ser Ql
Synonyms
Endomysium IgG Ser Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is This Test Measuring?

The test looks for IgG antibodies that target endomysium, a component of the stomach’s inner lining. These antibodies are produced when the immune system mistakenly attacks gluten in people with celiac disease. The presence of these antibodies suggests an immune response to gluten, which may indicate celiac disease or gluten sensitivity.

Why Might Your Doctor Order This Test?

Your doctor may recommend this test if you have symptoms like persistent diarrhea, abdominal pain, weight loss, fatigue, or a family history of celiac disease. It can also be used to monitor gluten-free diet compliance or check for undiagnosed cases in individuals with unexplained gastrointestinal issues.

What Are Common Symptoms Linked to This Test?

Celiac disease symptoms can vary widely but often include digestive problems (e.g., bloating, gas, or chronic diarrhea), nutritional deficiencies (e.g., anemia or osteoporosis), skin rashes, or long-term complications like malnutrition or joint pain. Some people may have no symptoms at all.

How Is This Test Performed?

A blood sample is drawn from a vein in your arm. The sample is sent to a lab for testing using an immunoassay method, which detects the presence of IgG antibodies against endomysium. Results are typically available within a few days.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Role in Diagnosing Celiac Disease

Short name

IgG Endomysial Antibodies

Frequently asked questions

What Does a Positive Test Mean?
A positive result strongly suggests celiac disease, but it is not definitive on its own. Your doctor may recommend additional tests, such as a gluten challenge (eating gluten while monitoring symptoms) or a biopsy of the small intestine, to confirm the diagnosis.
What If My Test Is Negative?
A negative result means you likely do not have celiac disease, but it does not rule out other gluten-related conditions. If you suspect gluten sensitivity, discuss other diagnostic options with your healthcare provider.
How Often Should I Get This Test?
This test is usually ordered once for diagnosis. If you are already on a gluten-free diet, it may be repeated occasionally to ensure compliance, but routine retesting is not standard unless symptoms or lab results suggest otherwise.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy