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Myoglobin (Serum) – Electrophoresis

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of myoglobin, a protein found in muscle tissue, in your blood. Myoglobin helps release oxygen to muscles during intense exercise or injury.

Quick summary

["Myoglobin can signal muscle damage or heart issues, helping doctors diagnose conditions quickly."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
51699-7
Short code
Endomysium IgG Titr Ser IF
Synonyms
Endomysium IgG Titr Ser IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
8
Ref high
61
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
CPT
82977
SNOMED
3110003
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you’ve experienced sudden chest pain, shortness of breath, or muscle pain, especially after trauma or intense exercise. It can also help assess conditions like heart attacks or muscle injuries.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from your arm. If you’re taking blood thinners or have a history of bleeding disorders, let your doctor know.

What the Results Mean

Elevated levels may indicate muscle damage (e.g., from a crash or overuse) or heart-related issues. Lower levels could be normal or due to certain medical conditions. Your doctor will interpret results in the context of your symptoms and health history.

Common Conditions Linked to Myoglobin Levels

High myoglobin can signal rhabdomyolysis (severe muscle breakdown), heart attacks, or other emergencies. Low levels may occur with dehydration or certain genetic disorders.

Reference range

Adult males: 8-61 U/L; Adult females: 5-36 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: Myoglobin is a sensitive marker for muscle and cardiac injury. It appears in blood shortly after damage, making it useful for early diagnosis of conditions like heart attacks or traumatic injuries. However, results alone aren’t diagnostic without clinical correlation.

Short name

Myoglobin Level (Serum)

Frequently asked questions

What causes myoglobin to rise in the blood?
Myoglobin levels can rise due to muscle trauma (e.g., car accidents, falls), intense exercise, or muscle diseases. Heart attacks or other severe conditions may also trigger elevated levels.
How soon after injury can myoglobin be detected?
Myoglobin appears in the blood within hours of muscle injury, often peaking around 6–12 hours. This makes it useful for diagnosing conditions like rhabdomyolysis or heart damage early.
Can myoglobin levels be affected by diet or supplements?
Dietary factors like protein intake may influence muscle myoglobin, but they don’t typically cause significant fluctuations in blood levels. Always discuss supplements with your doctor before testing.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy