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Eosinophil count in cerebrospinal fluid (CSF)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of eosinophils, a type of white blood cell, in your cerebrospinal fluid (the fluid surrounding the brain and spinal cord).

Quick summary

["Eosinophils in CSF may indicate certain infections or inflammatory conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
26451-5
Short code
Eosinophil NFr CSF
Synonyms
Eosinophil NFr CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What Is Eosinophil Count Used For?

Eosinophils are typically found in lower amounts in cerebrospinal fluid under normal conditions. When elevated, they may suggest conditions like parasitic infections, certain fungal infections, or inflammatory diseases such as sarcoidosis. This test helps doctors diagnose or monitor these conditions by examining fluid collected through a spinal tap.

When Might You Need This Test?

Your doctor may order this test if you have symptoms like severe headaches, neck stiffness, nausea, or if they suspect a condition affecting the central nervous system. It’s also used in cases where other tests or symptoms point toward eosinophilic meningitis or other eosinophil-related disorders.

How Is the Test Performed?

A small amount of cerebrospinal fluid is collected through a procedure called a lumbar puncture (spinal tap). The fluid is then sent to a lab for analysis, where eosinophils are counted under a microscope.

What Are Possible Results?

Results are typically reported as the number of eosinophils per microliter (µL) of CSF. While specific reference ranges can vary, elevated counts (above normal baseline) are key to identifying potential issues.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated eosinophil counts in CSF are often associated with parasitic infections (e.g., filariasis), certain fungal infections, or autoimmune/inflammatory conditions like eosinophilic meningitis. Low or normal counts usually indicate no significant eosinophilic activity unless other symptoms or tests support an alternative diagnosis.

Short name

CSF Eosinophil Count

Frequently asked questions

Why might my doctor suspect eosinophils in my CSF?
Your doctor may suspect eosinophils if you have symptoms like persistent headaches, neck stiffness, or unexplained neurological symptoms combined with lab findings or clinical suspicion of an eosinophil-related condition (e.g., eosinophilic meningitis, parasitic infection).
How long does it take to get results from this test?
Results from this test are typically available within 1–3 business days, depending on lab processing times. Your doctor will discuss the results with you during your follow-up visit.
Can I take anything special before this test?
No special preparations are needed for this test. You may drink fluids as usual, but avoid alcohol or medications that could affect spinal fluid composition unless instructed otherwise by your doctor.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy