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Eosinophil Count (Manual Differential Blood Count)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of eosinophils, a type of white blood cell, in your blood. Eosinophils help fight certain infections and respond to allergies and inflammation.

Quick summary

["Eosinophil levels can help diagnose or monitor conditions like allergies, asthma, parasitic infections, or other immune-related disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
12209-3
Short code
Eosinophil NFr Fld Manual
Synonyms
Eosinophil NFr Fld Manual
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
CPT
86430
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms like persistent itching, skin rashes, wheezing, or unexplained fatigue. It may also be used to check for conditions like parasitic infections, certain cancers, or reactions to medications.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm to draw blood. The process usually takes a few minutes. If you’re nervous, let your healthcare provider know.

What Happens During the Test?

Blood is collected in a tube and sent to the lab. A technician will manually count eosinophils under a microscope. This method provides detailed results for specific conditions.

What Do the Results Mean?

Results are reported as the number of eosinophils per microliter (µL) of blood. High levels may indicate allergies, infections, or inflammatory conditions, while low levels may suggest immune suppression or other health issues.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Eosinophils play a key role in defending against parasites, managing allergic reactions, and responding to chronic inflammation. Elevated counts can signal conditions like asthma, eosinophilic esophagitis, or certain cancers. Low counts may raise concerns about immune dysfunction or blood disorders.

Short name

Eosinophil Blood Test

Frequently asked questions

What causes eosinophil levels to be high?
High eosinophil counts can result from allergies, asthma, parasitic infections, certain cancers (like lymphoma), or autoimmune diseases. Chronic conditions like eosinophilic granulomatosis with polyangiitis may also be linked to elevated levels.
What causes eosinophil levels to be low?
Low eosinophil counts may occur due to infections (like viral or bacterial), certain medications, immune deficiencies, or blood disorders. Stress, malnutrition, or severe illness can also temporarily reduce their numbers.
How often should I get this test?
The frequency depends on your symptoms and medical history. Your healthcare provider will determine if follow-up testing is needed, such as every few months for chronic conditions or after treatment begins.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy