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Epidermal Growth Factor Receptor (EGFR) Mutation Analysis (Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for specific genetic changes in a protein called epidermal growth factor receptor (EGFR) that may be present in your blood. These changes can help determine if a certain type of lung cancer may respond to targeted therapies.

Quick summary

["This test helps guide treatment decisions for certain cancers by identifying genetic mutations linked to targeted drug effectiveness."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
18217-0
Short code
Epidis IgA Tiss Ql
Synonyms
Epidis IgA Tiss Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may recommend this test if you have or have had lung cancer, particularly non-small cell lung cancer (NSCLC). It is often used to check for EGFR mutations in plasma, which can help decide if a specific type of targeted cancer treatment might be beneficial.

How Is the Test Performed?

A small amount of your blood plasma is collected and sent to a laboratory. The lab uses advanced techniques, such as next-generation sequencing, to detect specific genetic mutations in EGFR. This process may take several days to complete.

What Does the Test Result Mean?

If EGFR mutations are found, it may indicate that a targeted therapy could be effective. If no mutations are detected, other types of treatment may be considered. Results are interpreted by a healthcare provider experienced in cancer genetics.

What Are the Possible Outcomes?

Possible outcomes include: (1) Presence of EGFR mutations, (2) Absence of EGFR mutations, or (3) Insufficient sample quality for analysis. Your results will be discussed with your doctor to tailor your treatment plan.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

EGFR Mutation Test (Plasma)

Frequently asked questions

What happens if my test result shows EGFR mutations?
If EGFR mutations are found, your doctor may recommend a targeted therapy designed to block the abnormal growth signals caused by these mutations. This treatment may be more effective for your type of cancer and could be an option if other treatments have not worked well.
What if my test result shows no EGFR mutations?
If no EGFR mutations are detected, your doctor may suggest other treatments, such as chemotherapy, immunotherapy, or radiation therapy. The choice of treatment will depend on your overall health, cancer stage, and other factors discussed with your healthcare team.
How often should I get this test?
The frequency of this test depends on your treatment plan and cancer progression. Your doctor will determine if retesting is needed during or after your cancer treatment, often based on clinical guidelines and your specific situation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy