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Erythropoietin (EPO) concentration in plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of erythropoietin, a hormone produced by your kidneys that helps your body make red blood cells. It may be checked to assess kidney function or evaluate conditions affecting red blood cell production.

Quick summary

["EPO levels help diagnose kidney issues or blood disorders that may affect red blood cell production."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
73399-8
Short code
EPO ind plt IgG SerPl Ql FC
Synonyms
EPO ind plt IgG SerPl Ql FC
Category
hematology
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test if you have symptoms like fatigue, shortness of breath, or pale skin, which could indicate low red blood cell counts. They might also order it to check kidney function, especially if you have chronic kidney disease or are on dialysis. Sometimes, it’s used to monitor treatment for conditions like anemia or certain cancers.

What to Expect Before the Test

No special preparation is usually needed. You may have a small needle inserted into a vein in your arm to draw a blood sample. If you’re on dialysis, your blood may be drawn during your treatment session. Avoid strenuous activity or eating for a short time before the test if instructed.

What to Expect During the Test

The blood sample is collected in a tube. The needle will be inserted, and you may feel a brief pinch. The process takes just a few minutes. The blood is then sent to a lab for testing.

What the Results Mean

Results are compared to a general reference range, but exact values can vary by lab. High levels might suggest kidney disease or certain cancers, while very low levels could indicate anemia or other blood disorders. Your provider will discuss these results with you in the context of your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

EPO Level

Frequently asked questions

How is this test different from hemoglobin or hematocrit tests?
This test specifically measures the hormone erythropoietin (EPO), which your kidneys produce to stimulate red blood cell production. Hemoglobin and hematocrit tests measure the actual red blood cells and their components, not the hormone that regulates them.
Can I eat or drink anything before this test?
Typically, no special diet is required, but follow any specific instructions your provider gives you. Some tests may require fasting, but this test does not. If you’re on dialysis, check with your provider about timing.
What does it feel like to have blood drawn?
Most people describe it as a brief, mild pinch or stinging sensation when the needle is inserted. Afterward, you may feel a small bruise or soreness at the site, but it usually goes away quickly. If you’re anxious, let your provider know—they may offer options to help you relax.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy