Alpha-1 Antitrypsin (Serum) Concentration

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like chronic coughing, wheezing, or difficulty breathing, especially if these symptoms started early in life. It may also be used to check for liver problems or if you have a family history of Alpha-1 Antitrypsin deficiency, a genetic condition that can affect both lungs and liver.

What to Expect Before the Test

No special preparation is needed for this blood test. You may have a small needle inserted into your arm to draw blood, and you’ll typically feel a brief pinch. If you’re on blood thinners, let your provider know before the test.

What the Results Mean

Results can help determine if your levels are too low, which may suggest a genetic disorder. Very low levels can increase your risk for lung diseases like emphysema or liver diseases like cirrhosis. Your provider will discuss the results with you in detail.

Common Conditions Linked to This Test

Low Alpha-1 Antitrypsin levels are often linked to Alpha-1 Antitrypsin deficiency, a condition passed down through families. It can cause lung diseases (such as chronic obstructive pulmonary disease) and liver diseases (such as cirrhosis). High levels may be seen in certain inflammatory conditions.