Estradiol (17β) mass concentration in serum/plasma
This test measures the amount of estradiol, a primary female sex hormone, in your blood. Estradiol plays a key role in reproductive health, bone density, and overall well-being.
["Estradiol levels help assess hormone balance, especially in women during different life stages like menstruation, pregnancy, or menopause."]
Key facts at a glance
- LOINC
- 12596-3
- Short code
- Estradiol 3h p chal SerPl-mCnc
- Synonyms
- Estradiol 3h p chal SerPl-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 20
- Ref high
- 400
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82670
- SNOMED
- 300919004
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Your healthcare provider may order this test to evaluate hormone-related conditions, such as irregular menstrual cycles, fertility issues, or symptoms of perimenopause/menopause. It may also be used to monitor hormone replacement therapy or check for conditions like ovarian tumors.
What to Expect Before the Test
No special preparation is usually needed, but you may be asked to fast for 8–12 hours if the test involves a blood draw. Avoid smoking or consuming alcohol before the test. Inform your provider about any medications you’re taking, as they may affect results.
What Happens During the Test?
A healthcare professional will draw blood from a vein in your arm. The sample is then sent to a lab for analysis using high-performance liquid chromatography (HPLC) to measure estradiol concentration accurately.
What Do the Results Mean?
Results are typically reported in picograms per milliliter (pg/mL) or similar units. While reference ranges vary by lab and individual factors, they help determine whether your hormone levels are within a healthy range for your age and health status.
Reference range
Premenopausal: 20-400 pg/mL; Postmenopausal: <30 pg/mLN/A
For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Estradiol levels can indicate reproductive health, bone health, and metabolic function. Low levels may signal conditions like premature ovarian insufficiency, while high levels could suggest polycystic ovary syndrome (PCOS), tumors, or other endocrine disorders. Monitoring estradiol helps guide treatment for hormonal imbalances or fertility planning.
Short name
Estradiol Level
Frequently asked questions
How long does it take to get results?
Can diet or medications affect estradiol levels?
Is this test painful?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy