Serum Estradiol Mass Concentration
This test measures the amount of estradiol, a key female sex hormone, in your blood serum. Estradiol plays a critical role in reproductive health, bone density, and overall well-being.
["Estradiol levels help assess hormonal balance, especially in women during different life stages like puberty, pregnancy, or menopause."]
Key facts at a glance
- LOINC
- 58485-4
- Short code
- Estradiol BS SerPl HS-mCnc
- Synonyms
- Estradiol BS SerPl HS-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 20
- Ref high
- 400
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- high-sensitivity
- CPT
- 82670
- SNOMED
- 300919004
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Your healthcare provider may order this test to evaluate symptoms like irregular periods, infertility, or signs of hormonal imbalances. It can also be used to monitor conditions such as polycystic ovary syndrome (PCOS), hormone replacement therapy, or to check for estrogen-related cancers.
What to Expect Before the Test
No special preparation is usually needed, but you may be asked to fast for 8–12 hours if your test involves a specific timing (e.g., pre-menstrual phase). Wear comfortable clothing for drawing blood, and let your provider know about any medications or supplements you’re taking.
What Happens During the Test?
A healthcare professional will insert a needle into a vein in your arm to draw a small amount of blood. The process is quick and typically painless. The blood sample is then sent to a lab for analysis.
What Are the Results Meaning?
Results help determine whether your estradiol levels are within a healthy range for your age and health status. Abnormally high or low levels may indicate underlying medical conditions that need further evaluation.
Reference range
Premenopausal: 20-400 pg/mL; Postmenopausal: <30 pg/mLN/A
For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Estradiol levels are vital for diagnosing hormonal disorders, guiding treatment for fertility issues, managing menopause symptoms, or assessing risks for conditions like breast cancer. They also support monitoring of hormone therapy and tracking changes in reproductive health over time.
Short name
Estradiol Level
Frequently asked questions
How long will it take to get my results?
What does a low estradiol level mean?
Can diet or exercise affect estradiol levels?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy