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Estradiol mass concentration in body fluids (serum/plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of estradiol, a key female sex hormone, in your blood. It helps assess hormone balance, reproductive health, and potential conditions like hormone-related cancers or menopause.

Quick summary

["Estradiol levels help diagnose and monitor hormone-related health issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
55857-7
Short code
Estradiol Fld-mCnc
Synonyms
Estradiol Fld-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
20
Ref high
400
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82670
SNOMED
300919004
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to evaluate symptoms like irregular menstrual cycles, breast tenderness, or signs of hormonal imbalances. It can also be used in fertility treatments, hormone replacement therapy planning, or monitoring conditions like ovarian or breast cancer.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if your lab requires a fasting sample. Bring a list of medications to your appointment.

What the Test Involves

A blood sample is drawn from a vein, typically in your arm. The sample is sent to a lab for analysis using a sensitive immunoassay method to measure estradiol concentration.

What the Results Mean

Results are compared to standard ranges for your age and sex, but individual values can vary. High or low levels may signal underlying health concerns that need further evaluation.

Reference range

Premenopausal: 20-400 pg/mL; Postmenopausal: <30 pg/mLN/A

Specimen: serum

For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Estradiol Level

Frequently asked questions

What causes estradiol levels to be unusually high or low?
High levels may be due to conditions like ovarian tumors, hormone therapy, or pregnancy. Low levels can result from menopause, polycystic ovary syndrome, or certain medications.
How often should I get this test?
Frequency depends on your medical needs. Your provider may recommend testing annually or more often if you’re undergoing hormone treatments or managing a condition like cancer.
Can diet or lifestyle affect estradiol levels?
Yes—diet, weight, exercise, and stress can influence hormone levels. Maintaining a balanced diet, managing weight, and reducing stress may help support healthy hormone balance.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy