Skip to content

Estradiol, Serum Concentration (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of estradiol, a form of estrogen, in your blood serum. Estradiol is a key hormone in women’s reproductive health and plays a role in regulating menstrual cycles, bone density, and overall well-being.

Quick summary

["Estradiol helps balance hormones and supports reproductive and metabolic health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
111267-1
Short code
Estradiol Msmt SerPl
Synonyms
Estradiol Msmt SerPl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
20
Ref high
400
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82670
SNOMED
300919004
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to evaluate symptoms like irregular periods, menopause-related changes, or fertility issues. It can also help diagnose conditions like ovarian cysts, hormonal imbalances, or certain cancers. Sometimes, it’s checked during pregnancy or before starting hormone therapy.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the draw if your lab requires it. Wear a loose shirt for easy access to your arm. Avoid smoking or caffeine right before the test, as they might affect results.

What Happens During the Test?

A healthcare professional will draw blood from a vein in your arm using a small needle. You may feel a slight pinch, but it’s quick and over in minutes. The blood sample is then sent to a lab for analysis.

What Are the Results Measured Against?

Results are compared to a general range of estradiol levels found in healthy individuals of different ages and stages of life (e.g., premenopausal, postmenopausal). Your actual range may vary based on your health status and lab’s reference data.

Reference range

Premenopausal: 20-400 pg/mL; Postmenopausal: <30 pg/mLN/A

Specimen: serum

For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Estradiol Level

Frequently asked questions

How Might My Results Affect My Care?
Low estradiol levels may indicate early menopause, ovarian dysfunction, or thyroid issues. High levels could suggest polycystic ovary syndrome (PCOS), tumors, or other hormonal disorders. Always discuss results with your provider—they’ll interpret them in the context of your health history and symptoms.
How Often Should I Get This Test?
Frequency depends on your reason for testing. For example, premenopausal women might get it annually, while postmenopausal women may need it less often. Your provider will determine the best schedule for you.
Can I Influence My Estradiol Levels?
Yes! Lifestyle factors like exercise, diet (e.g., phytoestrogens in soy), stress management, and avoiding smoking can impact hormone levels. Hormone therapy or medications may also affect estradiol, so talk to your provider about adjustments if needed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy