Estradiol (serum/plasma mass concentration)
This test measures the amount of estradiol, a key female sex hormone, in your blood. Estradiol helps regulate menstrual cycles, supports reproductive health, and influences bone and cardiovascular health.
["Understanding your estradiol levels can help assess reproductive function and overall hormone balance."]
Key facts at a glance
- LOINC
- 85068-5
- Short code
- Estradiol p Dex SerPl-mCnc
- Synonyms
- Estradiol p Dex SerPl-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 20
- Ref high
- 400
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82670
- SNOMED
- 300919004
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Doctors may order estradiol testing to evaluate symptoms like irregular periods, infertility, or menopause-related changes. It can also help diagnose conditions like polycystic ovary syndrome (PCOS), hormone-related cancers, or hormonal imbalances in men or transgender individuals undergoing hormone therapy.
What Does the Test Involve?
A blood sample is taken from a vein, usually in your arm. The sample is sent to a lab where it is analyzed to measure estradiol levels. Results are reported as a mass concentration in the blood.
What Are Common Results and Next Steps?
Results may be compared to general reference ranges for estradiol, though individual ranges can vary based on age, sex, and medical context. High or low levels may prompt further evaluation, such as additional hormone tests or imaging.
What Does It Mean If My Levels Are Abnormal?
High estradiol levels might suggest conditions like ovarian tumors, hormonal imbalances, or certain medications. Low levels could indicate premature ovarian failure, thyroid disorders, or other health issues. Your doctor will discuss findings in the context of your symptoms and medical history.
Reference range
Premenopausal: 20-400 pg/mL; Postmenopausal: <30 pg/mLN/A
For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: Estradiol plays critical roles in reproductive health, bone density, and cardiovascular function. Abnormal levels can impact fertility, menstrual cycles, bone strength, and even mood. Regular monitoring may be needed for individuals undergoing hormone therapy or managing chronic conditions like PCOS.
Short name
Estradiol Level
Frequently asked questions
What causes fluctuations in estradiol levels?
How often should I get this test?
Can lifestyle changes affect estradiol test results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy