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Serum/plasma estradiol mass concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of estradiol, a key female sex hormone, in your blood.

Quick summary

["Estradiol helps regulate menstrual cycles, supports reproductive health, and influences bone and cardiovascular health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
85066-9
Short code
Estradiol p LH SerPl-mCnc
Synonyms
Estradiol p LH SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
20
Ref high
400
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82670
SNOMED
300919004
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to evaluate symptoms like irregular periods, infertility, or signs of hormone-related conditions. It can also help diagnose conditions like polycystic ovary syndrome (PCOS), hormone imbalances, or certain cancers.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the draw if your lab uses a specific method. Wear a loose shirt for easy access to your vein.

What Happens During the Test?

A healthcare professional will draw blood from a vein in your arm using a small needle. You may feel a brief pinch, but it usually doesn’t cause discomfort. The blood is then sent to a lab for analysis.

What Does the Test Result Mean?

Results are compared to a general reference range, but your specific values will depend on factors like age, sex, and health status. High or low levels may signal underlying issues that need further evaluation.

Reference range

Premenopausal: 20-400 pg/mL; Postmenopausal: <30 pg/mLN/A

Specimen: serum

For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Estradiol Level

Frequently asked questions

How often do I need this test?
This test may be done once or multiple times depending on your symptoms, medical history, or treatment plan. Your provider will guide you on timing and frequency.
Can lifestyle changes affect estradiol levels?
Yes, factors like diet, exercise, stress, and certain medications can influence hormone levels. Avoiding smoking, managing stress, and maintaining a balanced diet may support stable hormone function.
What if my estradiol level is outside the normal range?
If your results are abnormal, your provider may recommend additional tests, lifestyle adjustments, or treatments to address potential imbalances. Follow-up visits will help monitor progress.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy