Estradiol (Serum) by Immunoassay
This test measures the amount of estradiol, a key female sex hormone, in your blood serum. Estradiol plays a critical role in reproductive health, bone density, and overall well-being.
["Estradiol helps regulate menstrual cycles, supports fertility, and influences energy and mood."]
Key facts at a glance
- LOINC
- 47617-6
- Short code
- Estradiol Pre ACTH SerPl-mCnc
- Synonyms
- Estradiol Pre ACTH SerPl-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 20
- Ref high
- 400
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82670
- SNOMED
- 300919004
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test to evaluate hormonal balance, diagnose conditions related to hormone imbalances, or monitor treatment for conditions like polycystic ovary syndrome (PCOS), menopause, or hormone-related cancers.
What to Expect Before the Test
No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if it involves a blood draw. Wear comfortable clothing and plan to stay near a testing facility for a short time.
How the Test Works
A small sample of your blood serum is collected and analyzed using an immunoassay method to detect and quantify estradiol levels. This method is highly sensitive and accurate for measuring hormone concentrations.
What the Results Mean
Results are typically reported in picograms per milliliter (pg/mL) or other standardized units. Interpretation depends on your age, sex, and medical history. Your healthcare provider will discuss these results with you in the context of your overall health.
Reference range
Premenopausal: 20-400 pg/mL; Postmenopausal: <30 pg/mLN/A
For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Estradiol levels can indicate reproductive health, fertility issues, or hormonal disorders. Low levels may suggest early menopause, ovarian dysfunction, or certain cancers, while elevated levels could signal conditions like ovarian tumors or hormonal imbalances. Regular monitoring helps manage symptoms and guide treatment.
Short name
Estradiol Level
Frequently asked questions
What causes estradiol levels to be checked?
How long does it take to get results?
Can lifestyle changes affect estradiol levels?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy