Estradiol (serum/plasma mass concentration)
This test measures the amount of estradiol, a primary female sex hormone, in your blood. Estradiol plays a key role in regulating menstrual cycles, pregnancy, and secondary sexual characteristics.
["Estradiol levels help assess reproductive health and potential hormonal imbalances."]
Key facts at a glance
- LOINC
- 83096-8
- Short code
- Estradiol SerPl IA-mCnc
- Synonyms
- Estradiol SerPl IA-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 20
- Ref high
- 400
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- ia
- CPT
- 82670
- SNOMED
- 300919004
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Doctors may order estradiol testing to evaluate symptoms like irregular periods, infertility, menopause-related issues, or to monitor hormone replacement therapy. It can also help diagnose conditions like polycystic ovary syndrome (PCOS) or evaluate hormone-related cancers.
What to Expect Before the Test
No special preparation is needed, but you may be asked to fast for 8–12 hours before the draw if your lab uses a specific method. Wear a loose shirt for easy access to your vein. If you’re taking hormonal medications, inform your provider beforehand.
What Happens During the Test?
A healthcare professional will draw blood from a vein in your arm using a small needle. You may feel a slight pinch, but the procedure usually takes less than 5 minutes. The blood sample is then sent to a lab for analysis.
What Are the Results Meaning?
Results are compared to a general reference range, but individual ranges can vary by lab and age. Low estradiol may indicate early menopause or hormonal deficiencies, while high levels could suggest conditions like ovarian tumors or excessive hormone exposure.
Reference range
Premenopausal: 20-400 pg/mL; Postmenopausal: <30 pg/mLN/A
For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Estradiol levels are critical for diagnosing hormonal disorders, guiding fertility treatments, and managing menopausal symptoms. Abnormal results may prompt further testing, such as follicle-stimulating hormone (FSH) or luteinizing hormone (LH) checks, to clarify underlying causes.
Short name
Estradiol Level
Frequently asked questions
How often should estradiol testing be done?
What does it mean if my estradiol level is low?
Can diet or supplements affect estradiol levels?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy