Estradiol (Serum/Plasma, Mass Concentration)
This test measures the amount of estradiol, a key female sex hormone, in your blood. Estradiol helps regulate menstrual cycles, supports reproductive health, and influences bone and cardiovascular health.
["Estradiol helps manage menstrual cycles and reproductive health."]
Key facts at a glance
- LOINC
- 58491-2
- Short code
- Estradiol sp2 p chal SerPl HS-mCnc
- Synonyms
- Estradiol sp2 p chal SerPl HS-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 20
- Ref high
- 400
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- high-sensitivity
- CPT
- 82670
- SNOMED
- 300919004
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Your healthcare provider may order an estradiol test to diagnose or monitor conditions like hormonal imbalances, menstrual irregularities, or symptoms of perimenopause or menopause. It can also help assess fertility, evaluate hormone therapy, or check for conditions like ovarian tumors.
What to Expect Before the Test
No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if serum is the specimen. If you’re taking certain medications (like birth control or hormone therapy), let your provider know. Avoid smoking or caffeine for 30 minutes before the draw.
What Happens During the Test?
A healthcare professional will draw blood from a vein in your arm. The sample is sent to a lab for analysis using a sensitive immunoassay method to measure estradiol levels accurately.
What Are the Results Meaning?
Results are compared to a reference range specific to your age, sex, and health status. Low or high levels may signal underlying health concerns that need further evaluation.
Reference range
Premenopausal: 20-400 pg/mL; Postmenopausal: <30 pg/mLN/A
For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Estradiol levels can indicate reproductive health, hormonal disorders, or menopausal status. Low levels may cause symptoms like hot flashes, irregular periods, or bone loss, while high levels could suggest conditions like ovarian tumors or polycystic ovary syndrome (PCOS). Regular monitoring helps guide treatment for hormone-related conditions.
Short name
Estradiol Level
Frequently asked questions
How long does it take to get my results?
What does a low estradiol level mean?
Can diet or exercise affect estradiol levels?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy