Estradiol (serum/plasma) by Immunoassay
This test measures the amount of estradiol, a key female sex hormone, in your blood. Estradiol helps regulate menstrual cycles, supports reproductive health, and influences bone and cardiovascular health.
["Estradiol helps balance hormones and supports reproductive and overall health."]
Key facts at a glance
- LOINC
- 51501-5
- Short code
- Estradiol sp2 p chal SerPl-mCnc
- Synonyms
- Estradiol sp2 p chal SerPl-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 20
- Ref high
- 400
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82670
- SNOMED
- 300919004
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Might You Need This Test?
Your healthcare provider may order an estradiol test to check for hormonal imbalances, evaluate symptoms like irregular periods, infertility, or menopause-related changes, or monitor treatment for hormone-related conditions. It may also be used in fertility planning or to diagnose conditions like polycystic ovary syndrome (PCOS).
What to Expect Before the Test
No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if your blood is drawn early in the morning. Wear comfortable clothing and arrange for someone to drive you home afterward, as you may feel lightheaded after blood collection.
What Happens During the Test?
A healthcare professional will draw blood from a vein in your arm. You may feel a slight pinch, but the process is quick. The blood sample is then sent to a lab for analysis using an immunoassay method to detect estradiol levels.
What Are the Results Meaning?
Results help identify whether your estradiol levels are too high or too low compared to what’s typical for your age and health status. High levels might suggest conditions like ovarian tumors or hormone therapy use, while low levels could indicate menopause, ovarian failure, or other hormonal disorders.
Reference range
Premenopausal: 20-400 pg/mL; Postmenopausal: <30 pg/mLN/A
For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
Estradiol Level
Frequently asked questions
What Does This Test Measure?
How Often Should I Get This Test?
Can I Take Anything Before the Test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy