Serum Estradiol Mass Concentration (by Immunoassay)
This test measures the amount of estradiol, a primary female sex hormone, in your blood serum. Estradiol plays a key role in regulating menstrual cycles, pregnancy, and secondary sexual characteristics.
["Understanding your estradiol levels can help assess reproductive health and hormone balance."]
Key facts at a glance
- LOINC
- 58817-8
- Short code
- Estradiol sp3 SerPl-mCnc
- Synonyms
- Estradiol sp3 SerPl-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 20
- Ref high
- 400
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82670
- SNOMED
- 300919004
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Your healthcare provider may order this test to evaluate symptoms such as irregular periods, menopause-related issues, or to monitor hormone therapy. It can also be used in fertility assessments or to check for conditions like polycystic ovary syndrome (PCOS).
What to Expect Before the Test
No special preparation is typically needed, but you may be asked to fast for 8–12 hours before the blood draw if your provider specifies it. Wear comfortable clothing and plan to stay near the testing site for a short time.
What Happens During the Test?
A healthcare professional will draw blood from a vein in your arm using a small needle. You may feel a brief pinch, but the procedure usually takes just a few minutes. The blood sample is then sent to a lab for analysis.
What Are the Results?
Results are reported as a mass concentration of estradiol in the blood. Your provider will interpret the results in relation to your age, health, and medical history. Abnormal levels may require further evaluation.
Reference range
Premenopausal: 20-400 pg/mL; Postmenopausal: <30 pg/mLN/A
For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Estradiol levels can indicate reproductive health, hormone imbalances, or underlying conditions. Low levels may suggest early menopause, ovarian dysfunction, or thyroid disorders, while high levels could signal tumors, cysts, or other hormonal issues. Regular monitoring helps manage conditions like PCOS or hormone replacement therapy effectively.
Short name
Estradiol Level
Frequently asked questions
How long does it take to get my results?
What does a low estradiol level mean?
Can diet or supplements affect estradiol levels?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy