Estradiol (serum/plasma, mass concentration)
This test measures the amount of estradiol, a key female sex hormone, in your blood. Estradiol helps regulate menstrual cycles, supports reproductive health, and influences bone and cardiovascular health.
["Estradiol levels can help diagnose hormonal imbalances or track changes during treatments like hormone therapy."]
Key facts at a glance
- LOINC
- 58488-8
- Short code
- Estradiol sp5 p chal SerPl HS-mCnc
- Synonyms
- Estradiol sp5 p chal SerPl HS-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 20
- Ref high
- 400
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- high-sensitivity
- CPT
- 82670
- SNOMED
- 300919004
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Your healthcare provider may order this test to evaluate symptoms like irregular periods, infertility, or signs of hormonal disorders. It can also be used during pregnancy, before starting hormone treatments, or to monitor conditions like polycystic ovary syndrome (PCOS).
What to Expect Before the Test
No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the draw if your lab uses a specific method. Bring any medications or supplements you’re taking to your appointment.
How the Test Is Performed
A blood sample is taken from a vein in your arm by a healthcare professional. The blood is then processed to measure estradiol levels using a sensitive lab technique, such as immunoassay.
What the Results Mean
Results are compared to a general reference range, but individual ranges can vary based on age, health status, and medical history. High or low levels may signal conditions like ovarian disorders, thyroid issues, or menopause-related changes.
Reference range
Premenopausal: 20-400 pg/mL; Postmenopausal: <30 pg/mLN/A
For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: Estradiol plays a critical role in reproductive health, bone density, and cardiovascular function. Abnormal levels may indicate underlying conditions requiring further evaluation, such as hormonal imbalances, cancers, or metabolic disorders.
Short name
Estradiol Level
Frequently asked questions
What causes estradiol levels to be tested?
How long does it take to get results?
Can lifestyle factors affect estradiol levels?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy