Estrogen (Estradiol) in Serum or Plasma
This test measures the amount of estradiol, a key female sex hormone, in your blood. Estradiol helps regulate menstrual cycles, supports reproductive health, and influences bone and cardiovascular health.
["Estradiol levels can help diagnose hormonal imbalances, fertility issues, or conditions affecting hormone production."]
Key facts at a glance
- LOINC
- 58484-7
- Short code
- Estradiol sp8 p chal SerPl HS-mCnc
- Synonyms
- Estradiol sp8 p chal SerPl HS-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 20
- Ref high
- 400
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- high-sensitivity
- CPT
- 82670
- SNOMED
- 300919004
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Your healthcare provider may order this test to evaluate symptoms like irregular periods, infertility, or signs of hormonal disorders. It can also be used during pregnancy monitoring, before hormone therapy, or to check for conditions like polycystic ovary syndrome (PCOS).
What to Expect Before the Test
No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if serum/plasma is required. Avoid smoking or caffeine for 30 minutes before drawing blood. Tell your provider about any medications or supplements you take, as they may affect results.
What Happens During the Test?
A healthcare professional will insert a needle into a vein in your arm to draw blood. You may feel a slight prick, but it usually doesn’t cause pain. The blood sample is then sent to a lab for analysis using an immunoassay method to measure estradiol concentration.
What Do the Results Mean?
Results are typically reported as a mass concentration (in pg/mL or similar units). While reference ranges vary by age, gender, and life stage, your provider will interpret results in relation to your specific health needs and symptoms.
Reference range
Premenopausal: 20-400 pg/mL; Postmenopausal: <30 pg/mLN/A
For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Estradiol levels can indicate hormonal health, fertility status, or potential issues like ovarian dysfunction, adrenal disorders, or thyroid problems. Low levels may suggest menopause, early puberty, or certain cancers, while high levels could signal tumors or hormonal imbalances. Always discuss results with your provider.
Short name
Estradiol Level
Frequently asked questions
How long does it take to get results?
Can diet or exercise affect estradiol levels?
Is this test painful?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy