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: Estradiol [Mass Concentration] in Tissue by Immunoassay

Published: August 9, 2026Updated: August 16, 2026

: This test measures the amount of estradiol, a form of estrogen, in a tissue sample using an immunoassay method. It is a specialized measurement that is not part of routine blood hormone testing.

Quick summary

[": This is a specialized tissue estradiol measurement; interpretation depends on the specific tissue sampled and clinical context."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
2245-9
Short code
Estradiol Tiss-sCnt
Synonyms
Estradiol Tiss-sCnt
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
20
Ref high
400
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82670
SNOMED
300919004
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

: What Is Being Measured

: Estradiol is the most potent naturally occurring estrogen and plays key roles in reproductive and other body functions. This test estimates how much estradiol is present in a sample of tissue rather than in blood or urine.

: How the Test Works

: An immunoassay uses antibodies that bind specifically to estradiol, producing a signal proportional to the amount present. The result is reported as a mass concentration (amount of estradiol per amount of tissue).

: Why Tissue Measurement Is Unusual

: Most estradiol testing is done on blood or saliva. Measuring estradiol directly in tissue is uncommon and is generally used in specialized research or selected clinical settings, so results are interpreted by the ordering provider in that context.

: What Results Can and Cannot Tell You

: A tissue estradiol result reflects the local level in the sampled area at the time of collection. Because tissue sampling and assay methods vary widely, results should be interpreted by your care team and not compared to standard blood estradiol ranges.

Reference range

Premenopausal: 20-400 pg/mL; Postmenopausal: <30 pg/mLN/A

Specimen: serum

For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

: NONE

Frequently asked questions

: Is this the same as a blood estradiol test?
: No. A blood estradiol test measures hormone circulating in the bloodstream, while this test measures estradiol within a tissue sample. The two are not directly interchangeable.
: Do I need to fast or prepare for this test?
: Preparation depends on how the tissue sample is collected and on your provider's instructions. Follow the specific guidance given by your care team.
: Can I compare my result to normal blood estradiol ranges?
: No. Tissue measurements use different specimens and methods, so they should not be compared with standard blood reference ranges. Ask your provider to explain what your result means for your situation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy