Estradiol mass concentration (serum/plasma)
This test measures the amount of estradiol, a key female sex hormone, in your blood. Estradiol helps regulate menstrual cycles, supports reproductive health, and influences bone and cardiovascular health.
["Estradiol levels help diagnose hormonal imbalances, fertility issues, or conditions like perimenopause."]
Key facts at a glance
- LOINC
- 12595-5
- Short code
- Estradiol Ur-mCnc
- Synonyms
- Estradiol Ur-mCnc
- Category
- chemistry
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Ref low
- 20
- Ref high
- 400
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82670
- SNOMED
- 300919004
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Your healthcare provider may order estradiol testing to check for hormonal disorders, evaluate symptoms like irregular periods or hot flashes, assess fertility, or monitor treatment for conditions like polycystic ovary syndrome (PCOS) or hormone replacement therapy.
What to Expect Before the Test
No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the draw if your test involves a blood sample. Wear comfortable clothing and plan to sit or lie down for a short time afterward.
How the Test Works
A healthcare professional will draw blood from a vein in your arm. The sample is then analyzed to measure estradiol concentration using a sensitive laboratory method, often an immunoassay.
What the Results Mean
Results are reported in mass concentration units (e.g., picograms per milliliter, pg/mL). Your results will be compared to reference ranges specific to your age, sex, and menstrual cycle phase (if applicable).
Reference range
Premenopausal: 20-400 pg/mL; Postmenopausal: <30 pg/mLN/A
For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Estradiol Level
Frequently asked questions
How often should I get this test?
What are typical reference ranges for estradiol?
Can lifestyle changes affect estradiol levels?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy