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Estrogen and Creatinine, 24-Hour Urine

Published: August 9, 2026Updated: August 16, 2026

Measures estrogen and creatinine in urine collected for 24 hours; creatinine helps account for differences in urine concentration.

Quick summary

["This test estimates estrogen excretion over 24 hours and checks the adequacy of the urine collection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
13738-0
Short code
Estrogen/Creat 24h Ur
Synonyms
Estrogen/Creat 24h Ur
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures estrogen and creatinine in a urine sample collected over 24 hours. Estrogen is a group of hormones involved in female reproductive health, while creatinine helps show how concentrated the urine is and whether the collection appears adequate.

Why might I need this test?

A clinician may use this test to evaluate estrogen production, ovarian function, fertility concerns, menopausal changes, or symptoms related to hormonal imbalance. Measuring creatinine with estrogen can help reduce the effect of variations in urine concentration.

How is the test performed?

You collect all urine produced during a full 24-hour period according to the instructions provided by the laboratory or healthcare professional. The container and any refrigeration requirements will depend on the laboratory's collection kit, and the total volume is recorded and sent for analysis.

How do I prepare for the test?

Follow the collection instructions carefully and note the start and finish times. Tell your clinician about medicines, supplements, pregnancy, or recent hormonal treatment, because these can affect estrogen results; do not stop prescribed medicines unless instructed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

An estrogen result that differs from the expected range may reflect the timing of the menstrual cycle, menopause, changes in ovarian function, medication effects, or conditions that alter estrogen production. The 24-hour creatinine measurement and collection details help determine how the urine result should be interpreted. Your clinician will consider symptoms and other tests along with this result.

Short name

24-Hour Urine Estrogen and Creatinine

Frequently asked questions

Do I need to fast for this test?
Fasting is generally not required, but follow any specific instructions from your clinician or laboratory. Diet, hydration, medications, and supplements may affect results or urine collection.
What happens if I miss part of the 24-hour urine collection?
A missed collection can make the result less accurate, and the laboratory may ask you to repeat it. If you are unsure how to proceed, contact the collection site for instructions.
Why is creatinine measured with urine estrogen?
Urine concentration can vary from day to day. Creatinine provides context for interpreting the estrogen measurement and helps assess whether the collection appears adequate.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy