Total Estrogen and Creatinine, Urine — Substance Ratio
This urine test compares the amount of total estrogen with the amount of creatinine, helping account for differences in urine concentration.
["The result provides a concentration-adjusted measure of urinary estrogen but must be interpreted with symptoms, medications, and collection timing."]
Key facts at a glance
- LOINC
- 34296-4
- Short code
- Estrogen/Creat Ur-sRto
- Synonyms
- Estrogen/Creat Ur-sRto
- Category
- kidney
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What is this test?
This test measures total estrogen and creatinine in urine and calculates their ratio. Creatinine is used as a reference to help adjust for variations in urine concentration.
Why might I need this test?
A provider may order it to evaluate estrogen production, menstrual or fertility concerns, abnormal puberty, or symptoms suggesting too much or too little estrogen. It may also be used to monitor certain hormonal conditions or treatments.
How is the test performed?
The laboratory measures estrogen and creatinine in a urine sample and calculates the estrogen-to-creatinine ratio. The urine may be a single sample or part of a timed collection, depending on the instructions provided by your clinician.
How do I prepare for the test?
Follow the collection instructions exactly and tell your clinician about pregnancy, recent menstrual timing, hormonal medications, supplements, and other medicines that may affect estrogen. If a timed collection is required, record the collection period and keep the container refrigerated if instructed.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
A higher ratio may reflect increased estrogen production, which can occur with pregnancy, normal reproductive states, or less commonly estrogen-producing conditions. A lower ratio may be associated with reduced estrogen production, such as ovarian insufficiency, and can also occur when urinary creatinine is relatively high. Results should be interpreted with symptoms, age, menstrual or pregnancy status, medications, and collection timing because these factors can affect the ratio.
Short name
Urinary estrogen-to-creatinine ratio
Frequently asked questions
Does this test diagnose a specific condition?
Why is creatinine included?
Does the test require a 24-hour urine collection?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy