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Estrogen (Serum) Mass Concentration

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of estrogen, a key hormone in women’s reproductive health, present in your blood serum. Estrogen levels can vary based on age, menstrual cycle, and health conditions.

Quick summary

["Estrogen levels help assess reproductive function, hormone balance, and potential health risks."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
2254-1
Short code
Estrogen SerPl-mCnc
Synonyms
Estrogen SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
17
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to evaluate symptoms like irregular periods, infertility, or signs of hormonal imbalances. It can also help diagnose conditions such as polycystic ovary syndrome (PCOS), ovarian cysts, or hormone-related cancers.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the draw if your lab requires it. Wear a loose shirt for easy access to your vein.

How the Test Is Performed

A healthcare professional will insert a needle into a vein in your arm to collect blood. The blood will be sent to a lab for analysis of estrogen concentration.

What the Results Mean

Results are compared to reference ranges specific to your age, sex, and menstrual cycle phase (if applicable). Abnormal levels may signal hormonal disorders or other health concerns requiring further evaluation.

Reference range

NCBI: NSE 0-17 ng/mLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Estrogen plays a critical role in bone health, cardiovascular function, and reproductive processes. Low levels may indicate menopause, hormonal deficiencies, or thyroid disorders, while high levels could signal tumors or other endocrine issues. Regular monitoring helps manage conditions like PCOS or perimenopause.

Short name

Serum Estrogen Level

Frequently asked questions

How Often Should I Get This Test?
The frequency depends on your health status. For example, women with PCOS may need testing every 6–12 months, while others may only need it during specific evaluations (e.g., pre-menopause, fertility planning). Always follow your provider’s recommendations.
What Are Common Causes of Abnormal Results?
Factors like pregnancy, certain medications (e.g., birth control), thyroid disorders, or liver disease can affect estrogen levels. Stress, weight changes, or smoking may also influence results.
Can I Adjust My Diet Before the Test?
Generally, no dietary restrictions are required unless specified by your lab. However, avoid alcohol and caffeine for 24 hours before testing, as they may impact hormone levels.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy