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Estrogen (Total) Mass Concentration in Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of estrogen hormones in your blood, which can help assess reproductive health, hormone balance, or potential conditions like polycystic ovary syndrome (PCOS) or menopause-related changes.

Quick summary

["Your estrogen levels help guide decisions about fertility, hormone therapy, or other health management plans."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58818-6
Short code
Estrogen sp2 SerPl-mCnc
Synonyms
Estrogen sp2 SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order a total estrogen test to evaluate symptoms such as irregular periods, infertility, or signs of hormonal imbalances. It can also be used during pregnancy monitoring, before or after hormone treatments, or to diagnose conditions affecting estrogen production or metabolism.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the blood draw if instructed by your healthcare provider. Wear comfortable clothing and plan for a short visit to a lab or clinic.

During the Test

A healthcare professional will insert a small needle into a vein in your arm to collect blood. You may feel a brief pinch, but the process is quick. The blood sample is then sent to a lab for analysis.

What the Results Mean

Results are typically reported as a mass concentration (e.g., in picograms per milliliter or nanograms per deciliter), but your doctor will interpret them in relation to your age, sex, and medical history. Abnormal levels may signal hormonal disorders or other health concerns.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Estrogen Level

Frequently asked questions

What could high or low estrogen levels indicate?
High estrogen levels might suggest conditions like ovarian cysts, hormone therapy use, or liver disease. Low levels could indicate premature menopause, thyroid disorders, or conditions affecting hormone production, such as PCOS or pituitary issues.
How do estrogen levels change with age?
Estrogen naturally declines with age, especially after menopause, which can lead to symptoms like hot flashes or bone density changes. Your doctor may track these changes over time to monitor progression or guide treatment.
Can diet or lifestyle affect estrogen levels?
Yes, factors like diet (e.g., phytoestrogens in soy), weight, exercise, and stress can influence estrogen. Maintaining a balanced diet, managing weight, and reducing stress may help support healthy hormone levels.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy