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: Excess Residual Cytoplasm (Neutrophil Fluorescence Reduction) Measurement

Published: August 9, 2026Updated: August 16, 2026

: This test measures the amount of leftover cytoplasm in neutrophils, a type of white blood cell, using a fluorescence-based method. It is a specialized laboratory measurement that may help evaluate how neutrophils mature and function.

Quick summary

[": The test quantifies excess residual cytoplasm in neutrophils as an indicator of cell maturation and health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
90047-2
Short code
Excess residual cytoplasm NFr Smn
Synonyms
Excess residual cytoplasm NFr Smn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

: What Is Being Measured

: Neutrophils are white blood cells that help fight infection. As they mature, they normally lose most of their internal fluid (cytoplasm). This test estimates how much cytoplasm remains, referred to as excess residual cytoplasm, using a fluorescence signal that is reduced when less cytoplasm is present.

: How the Test Works

: A blood sample is processed in the laboratory so that neutrophils can be examined with a fluorescence-based measurement. The instrument detects a signal related to the cytoplasm content of these cells. The term "fluorescence reduction" indicates that the measured signal changes depending on how much residual cytoplasm is present.

: Why Your Doctor May Order It

: This is not a routine test. It may be used in specialized settings to study neutrophil maturation or to support evaluation of certain blood or immune conditions. Your doctor will interpret the result alongside your medical history, other blood counts, and additional tests.

: What the Results Mean

: Results are reported by the laboratory using its own method and reference information, so the meaning depends on the specific testing system. An abnormal value alone does not diagnose a condition. Your care team will explain what your result suggests in the context of your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

: Changes in neutrophil cytoplasm and maturation can be seen in some blood disorders and immune conditions, so this measurement may provide supportive information. However, it is a specialized research or reference-laboratory type of test, and its clinical usefulness depends on the specific method and the broader clinical picture.

Short name

: NONE

Frequently asked questions

: Is this a standard blood test?
: No. Excess residual cytoplasm measurement by fluorescence is a specialized laboratory test, not part of routine blood work such as a complete blood count.
: Does an abnormal result mean I have a disease?
: Not necessarily. Results must be interpreted by your doctor along with your symptoms, other laboratory findings, and medical history.
: How is the sample collected?
: It is typically collected from a blood sample, but the exact specimen and processing requirements are set by the performing laboratory. Follow your provider's instructions for collection.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy