Brain-derived neurotrophic factor (BDNF) in serum/plasma

What Is Brain-Derived Neurotrophic Factor (BDNF)?

BDNF, or brain-derived neurotrophic factor, is a protein produced by cells in the brain and nervous system. It plays a critical role in maintaining and promoting the survival of neurons, which are essential for transmitting signals in the brain and body. Levels of BDNF can vary based on health conditions, stress, and lifestyle factors.

Why Might You Need This Test?

Your healthcare provider may order a BDNF test if you have symptoms or conditions linked to nerve or brain health, such as depression, anxiety, or neurological disorders. It may also be used in research or clinical studies to evaluate mental health or nerve function.

How Is the Test Performed?

A small blood sample is drawn from a vein, usually in your arm. The sample is then sent to a lab for analysis using an immunoassay method to measure BDNF levels.

What Do Results Mean?

Results are typically reported as a concentration of BDNF in the blood. While reference ranges can vary by lab, lower levels may be associated with conditions affecting nerve health or mood, while higher levels might indicate other health factors. Your provider will interpret results in the context of your overall health and symptoms.