Full-length sequencing analysis of the F13A1 gene (Factor XIII A Subunit)

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have a family history of bleeding disorders, recurrent clotting issues, or symptoms like excessive bruising, prolonged bleeding from cuts, or unexplained nosebleeds. It’s also used in genetic counseling for conditions linked to Factor XIII deficiencies.

What to Expect Before the Test

No special preparation is needed. A blood sample will be drawn from a vein in your arm, similar to other blood tests. You may feel a slight pinch, but it’s usually over quickly. If you’re pregnant or have a history of clotting issues, let your provider know before the test.

What the Test Results Mean

Results will show whether any mutations are present in the F13A1 gene. Normal results mean the gene appears intact, while abnormal findings may indicate inherited bleeding disorders or other clotting-related conditions. Your provider will discuss these findings with you in detail.

Common Conditions Linked to This Test

Mutations in the F13A1 gene can lead to Factor XIII deficiency, which may cause bleeding disorders. This test helps diagnose conditions like autosomal recessive congenital afibrinogenemia or hypofibrinogenemia, where blood clotting is impaired due to low or absent Factor XIII.