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Total Protein in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein found in your blood serum. Proteins help transport nutrients, fight infections, and maintain fluid balance in your body.

Quick summary

["Your blood protein levels can indicate overall health and help diagnose certain conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
24475-6
Short code
F2 c.20210G>A Geno Bld/T
Synonyms
F2 c.20210G>A Geno Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Doctors may order a total protein test to check for conditions like malnutrition, kidney disease, liver problems, or certain types of cancer. It can also help monitor long-term health in people with chronic illnesses.

What Does the Test Involve?

A small blood sample is taken from a vein, usually in your arm. The blood is then sent to a lab where it is processed to separate serum (the liquid part after clotting) for testing.

What Are Common Results?

Results are typically reported in grams per deciliter (g/dL). While specific reference ranges vary by lab, lower than expected levels may suggest malnutrition or liver/kidney issues, while higher levels could indicate dehydration, inflammation, or certain diseases.

What Can Affect Results?

Factors like dehydration, certain medications, or recent illness can influence protein levels. It’s important to inform your doctor about any medications or conditions that might affect test results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Total protein levels can provide clues about your body’s overall protein status. Low protein levels may signal conditions like cirrhosis, kidney disease, or severe malnutrition. High levels might indicate dehydration, chronic inflammation, or certain autoimmune disorders. Monitoring protein levels is also useful in managing long-term health conditions.

Short name

Total Protein

Frequently asked questions

How long does it take to get my results?
Results are usually available within 1 to 3 business days, depending on your lab and healthcare provider’s process.
What does a low total protein level mean?
A low total protein level may suggest problems with protein absorption, liver or kidney disease, or severe malnutrition. Your doctor will discuss this with you based on your overall health and test results.
Can I eat or drink before this test?
You can eat and drink normally before this test, as it does not require fasting. However, always follow your doctor’s specific instructions for your appointment.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy