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Total Protein in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes albumin and other proteins like globulins.

Quick summary

["Your blood protein levels help doctors assess overall health and detect potential issues like kidney disease or malnutrition."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
91712-0
Short code
F5 c.1691G>A Geno Bld/T
Synonyms
F5 c.1691G>A Geno Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Is Protein in Blood?

Proteins in blood are essential for many bodily functions, including maintaining fluid balance, supporting immune responses, and transporting nutrients. Albumin, the most abundant protein, helps keep fluids in your blood vessels, while globulins assist with immune defense and blood clotting. Together, they contribute to your body’s overall health and stability.

Why Might This Test Be Ordered?

Doctors may order this test to check for conditions like kidney disease (where protein leaks into urine), liver problems (which affect protein production), dehydration, malnutrition, or certain immune disorders. It can also help monitor treatment progress in patients with chronic illnesses.

How Is the Test Performed?

A small blood sample is drawn from your arm, typically in a clinic or lab. The serum (liquid part of blood after clotting) is then analyzed to measure total protein content using automated laboratory methods.

What Are Common Results?

Results are reported in grams per deciliter (g/dL). While exact reference ranges vary by lab, low levels may suggest malnutrition or liver/kidney issues, while high levels could indicate dehydration or conditions like multiple myeloma.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal protein levels can signal underlying health problems. Low protein levels may indicate poor nutrient absorption, liver disease, or kidney dysfunction, while elevated levels could suggest dehydration, inflammation, or certain blood disorders. Regular monitoring helps track these conditions effectively.

Short name

Total Protein

Frequently asked questions

What Does a Low Total Protein Level Mean?
A low total protein level might mean your body isn’t producing enough protein or isn’t absorbing nutrients properly. This could be due to liver disease, kidney problems, severe malnutrition, or chronic infections. Your doctor may recommend further tests to identify the cause.
What Does a High Total Protein Level Mean?
High protein levels can result from dehydration, certain blood disorders (like multiple myeloma), or conditions causing inflammation. If your doctor finds elevated results, they may check for underlying causes like infections, kidney disease, or medications affecting protein balance.
How Often Should I Get This Test?
Frequency depends on your health status. If you have a chronic condition like kidney or liver disease, your doctor may order this test regularly. Otherwise, it’s often done as needed for specific symptoms or diagnostic purposes.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy