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: F8 Gene Mutation Analysis, Whole Blood

Published: August 9, 2026Updated: August 16, 2026

: This test looks for changes (mutations) in the F8 gene using a blood sample. The F8 gene provides instructions for making factor VIII, a protein involved in blood clotting.

Quick summary

[": F8 gene testing can identify genetic changes associated with factor VIII deficiency and help clarify why a person may have a bleeding disorder."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
21672-1
Short code
F8 gene Mut Anl Bld/T
Synonyms
F8 gene Mut Anl Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

: What This Test Examines

: The F8 gene carries the instructions for producing factor VIII, a clotting protein. This test analyzes the gene to detect variants that may affect how much factor VIII is made or how well it works. Testing is typically done on DNA extracted from a whole blood sample.

: Why It May Be Ordered

: Doctors may request F8 gene testing when a person has signs of a bleeding disorder, has abnormal factor VIII clotting activity, or has a family history of factor VIII deficiency. It can help confirm a genetic cause and inform family planning discussions.

: How the Sample Is Collected

: A small blood sample is drawn from a vein, usually in the arm, and sent to a specialized laboratory. The laboratory extracts DNA and examines the F8 gene for sequence changes or other alterations.

: What Results Can Mean

: A result may identify a genetic variant in F8, which can help explain low or poorly functioning factor VIII. Sometimes a variant of uncertain significance is found, meaning its effect on health is not yet clear. Results should always be interpreted together with clotting tests and clinical findings by a healthcare provider or genetic counselor.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

: F8 Mutation

Frequently asked questions

: Is this the same as a factor VIII activity blood test?
: No. A factor VIII activity test measures how well the clotting protein works in your blood, while F8 gene testing looks for DNA changes that may cause abnormal factor VIII. They provide different but complementary information.
: Do I need genetic counseling before this test?
: Genetic counseling is often recommended so you understand what the test can and cannot tell you, possible implications for family members, and how results may affect care. Your healthcare provider can help arrange this.
: Can a normal result rule out a bleeding disorder?
: Not necessarily. Some bleeding disorders are caused by factors other than F8 gene changes, and some genetic changes may not be detected by a particular testing method. Your provider will interpret results alongside your symptoms and other laboratory tests.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy