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Genetic mutation analysis for intron 22 of the Factor IX gene (F9) via next-generation sequencing

Published: August 9, 2026Updated: August 16, 2026

This test checks for genetic changes in the intron 22 region of the Factor IX gene, which is linked to bleeding disorders like hemophilia B.

Quick summary

["Helps identify inherited genetic variations that may affect blood clotting function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
91679-1
Short code
F8 intron 22 Inv Mut Anl Bld/T
Synonyms
F8 intron 22 Inv Mut Anl Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may recommend this test if you or a family member has symptoms of bleeding disorders, a history of hemophilia B, or unexplained bleeding or bruising. It may also be part of prenatal testing if there’s a family history of Factor IX-related conditions.

What to Expect Before the Test

No special preparation is needed. If you’re undergoing prenatal testing, a blood sample may be taken from you or your partner. For other cases, a blood sample is typically drawn from a vein in your arm.

What the Test Results Mean

Results will indicate whether the intron 22 mutation is present. A positive result means you carry the genetic variation linked to hemophilia B risk. Consult your provider for interpretation and next steps.

Common Causes for Testing

Testing is often triggered by a suspected bleeding disorder, family history, or genetic counseling recommendations. It helps confirm or rule out inherited mutations before symptoms appear.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Factor IX is a protein in blood that helps form clots. Mutations in this gene can impair its function, leading to hemophilia B—a genetic disorder causing excessive bleeding. Early detection allows for proactive management and treatment planning.

Short name

F9 Intron 22 Mutation Screening (NGS)

Frequently asked questions

Will this test affect my insurance coverage?
Insurance coverage depends on your plan and reason for testing. Confirm with your provider or insurance company before scheduling. Genetic testing may be covered if medically necessary.
How long will I need to wait for results?
Results typically take 2–4 weeks, depending on lab processing and follow-up steps. Your healthcare team will guide you on next actions if needed.
Can I donate blood if I have this test?
If you’re diagnosed with a Factor IX mutation, blood donation may be restricted until further evaluation by your provider. Always check with them before donating.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy