Factor I (Activated Clotting Time) – Plasma
This test measures how long it takes for blood plasma to clot after activation, helping assess blood clotting function.
["ACT helps diagnose bleeding or clotting disorders by tracking how quickly your blood forms a clot under controlled conditions."]
Key facts at a glance
- LOINC
- 96455-1
- Short code
- Fact II Act + Inhib Pnl PPP
- Synonyms
- Fact II Act + Inhib Pnl PPP
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- coag
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Is ACT Used For?
ACT is primarily used in medical settings to monitor blood clotting during procedures like cardiopulmonary bypass, dialysis, or when evaluating patients with suspected bleeding or clotting disorders. It provides a quick baseline measurement of clotting efficiency in plasma.
How Is the Test Performed?
A small sample of your blood is drawn into a specialized tube containing a clotting activator. The blood is then placed in a device that measures the time it takes for a clot to form. This process is typically done in a clinical lab under sterile conditions.
Sample Requirements and Preparation
For this test, you’ll need a blood sample collected in a special tube. No special preparation is required, but fasting may be advised in some cases depending on the clinical context (e.g., monitoring anticoagulant therapy).
What Does an Abnormal ACT Indicate?
An ACT that is too long may suggest impaired clotting (e.g., due to bleeding disorders, low levels of clotting factors, or medications like anticoagulants). An ACT that is too short may indicate hypercoagulability or laboratory contamination. Results are interpreted in relation to clinical symptoms and other lab tests.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
ACT (Activated Clotting Time)
Frequently asked questions
Why might my doctor order an ACT?
What are the typical reference ranges for ACT?
Can I influence my ACT results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy