Factor Inhibitor Activity in Plasma (e.g., Antithrombin Activity)
This test measures the activity level of antithrombin, a natural protein in your blood that helps prevent abnormal blood clotting. It may be checked if you have a history of bleeding disorders, clotting issues, or are taking blood-thinning medications.
["Antithrombin helps regulate blood clotting; low levels may increase risk of bleeding or clotting problems."]
Key facts at a glance
- LOINC
- 13591-3
- Short code
- Fact Inhib XXX PPP-aCnc
- Synonyms
- Fact Inhib XXX PPP-aCnc
- Category
- chemistry
- Sample
- plasma
- Container
- Lavender-top (EDTA) or Green-top (Heparin)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- coag
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may order this test if you have symptoms like easy bruising, excessive bleeding, or unexplained clots. It’s also used to monitor conditions like antithrombin deficiency or to check how well blood-thinning treatments are working. Sometimes, it’s part of a broader evaluation for inherited or acquired clotting disorders.
What to Expect Before the Test
No special preparation is usually needed, but you may be asked to fast for a few hours before your blood draw if your provider specifies it. Bring a list of all medications or supplements you take, as some can affect test results. Avoid strenuous activity or eating heavy meals right before the test.
What the Test Involves
A healthcare professional will draw blood from a vein in your arm using a small needle. You may feel a brief pinch, but it’s typically over quickly. The blood sample is then sent to a lab for analysis. The process usually takes less than 15 minutes.
What the Results Mean
Results are compared to a standard range, but exact values can vary by lab. Low antithrombin activity may indicate a bleeding disorder or an increased risk of clotting, depending on your medical history. High levels might suggest certain liver conditions or medications that boost clotting. Your provider will discuss the results in the context of your overall health.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Antithrombin is a critical protein in the blood’s clotting system. When levels are too low, you may be at higher risk for bleeding (e.g., nosebleeds, heavy periods, or easy bruising). Conversely, low levels can also increase the risk of clots, especially in people with certain genetic conditions. Regular monitoring is important for those with antithrombin deficiency or those on anticoagulant therapy to ensure the medication is effectively preventing clots without causing excessive bleeding.
Short name
Antithrombin Activity
Frequently asked questions
How long does it take to get my results?
Can I eat or drink before this test?
Will this test affect my medications?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy