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Factor Inhibitor Activity in Plasma (e.g., Antithrombin Activity)

Published: August 9, 2026Updated: August 16, 2026

This test measures the activity level of antithrombin, a natural protein in your blood that helps prevent abnormal blood clotting. It may be checked if you have a history of bleeding disorders, clotting issues, or are taking blood-thinning medications.

Quick summary

["Antithrombin helps regulate blood clotting; low levels may increase risk of bleeding or clotting problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
13591-3
Short code
Fact Inhib XXX PPP-aCnc
Synonyms
Fact Inhib XXX PPP-aCnc
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
coag
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test if you have symptoms like easy bruising, excessive bleeding, or unexplained clots. It’s also used to monitor conditions like antithrombin deficiency or to check how well blood-thinning treatments are working. Sometimes, it’s part of a broader evaluation for inherited or acquired clotting disorders.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for a few hours before your blood draw if your provider specifies it. Bring a list of all medications or supplements you take, as some can affect test results. Avoid strenuous activity or eating heavy meals right before the test.

What the Test Involves

A healthcare professional will draw blood from a vein in your arm using a small needle. You may feel a brief pinch, but it’s typically over quickly. The blood sample is then sent to a lab for analysis. The process usually takes less than 15 minutes.

What the Results Mean

Results are compared to a standard range, but exact values can vary by lab. Low antithrombin activity may indicate a bleeding disorder or an increased risk of clotting, depending on your medical history. High levels might suggest certain liver conditions or medications that boost clotting. Your provider will discuss the results in the context of your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Antithrombin is a critical protein in the blood’s clotting system. When levels are too low, you may be at higher risk for bleeding (e.g., nosebleeds, heavy periods, or easy bruising). Conversely, low levels can also increase the risk of clots, especially in people with certain genetic conditions. Regular monitoring is important for those with antithrombin deficiency or those on anticoagulant therapy to ensure the medication is effectively preventing clots without causing excessive bleeding.

Short name

Antithrombin Activity

Frequently asked questions

How long does it take to get my results?
Results are typically available within 1 to 3 business days, depending on your lab and testing schedule. Some labs may provide preliminary results sooner, but your provider will confirm the final report.
Can I eat or drink before this test?
Most often, no fasting is required, but your provider may instruct you to avoid food for a few hours if specified. Always follow their guidance to ensure accurate results.
Will this test affect my medications?
Some medications, like blood thinners (e.g., warfarin or heparin), can influence antithrombin levels. If you’re on these or other medications, let your provider know to avoid any unexpected interactions.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy