Skip to content

Factor VII Activity (Prothrombin Complex Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the activity level of Factor VII, a protein involved in blood clotting. Low levels may indicate bleeding disorders or liver disease.

Quick summary

["Factor VII helps control bleeding; low levels may signal hidden bleeding risks or liver health issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
3203-7
Short code
Fact VII+ACA Ag Act/Nor PPP IA
Synonyms
Fact VII+ACA Ag Act/Nor PPP IA
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you have symptoms of easy bruising, prolonged bleeding, or unexplained internal bleeding. It’s also used to monitor treatment for bleeding disorders or liver conditions that affect clotting.

What to Expect Before the Test

No special preparation is needed. You’ll likely have a blood sample drawn from a vein in your arm. Tell your healthcare provider about any medications, especially blood thinners, or recent injuries.

What the Results Mean

Results are often expressed as a percentage of normal activity. A result below 20% may indicate severe bleeding risk, while levels between 20%–50% may suggest moderate risk. Results above 50% are typically within normal range.

Common Causes of Abnormal Results

Low Factor VII activity can be caused by liver disease, vitamin K deficiency, certain medications (like blood thinners), or inherited bleeding disorders. High levels are less common but may occur with certain blood disorders or overproduction in the liver.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Factor VII Activity

Frequently asked questions

What Does This Test Tell Your Doctor?
Low Factor VII activity can signal bleeding disorders or liver dysfunction, which may require further testing or treatment adjustments. High levels may need investigation for underlying conditions affecting blood clotting.
When Might I Need Follow-Up?
If your results are abnormal, your doctor may recommend additional tests (like liver function tests) or adjust medications to improve clotting. Follow-up may also be needed if you experience bleeding symptoms.
How Long Does It Take to Get Results?
Results are typically available within 1–3 business days, depending on your lab. Your doctor will discuss them with you during your follow-up visit.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy