Factor VII Activity (Prothrombin Complex Concentration)
This test measures the activity level of Factor VII, a protein involved in blood clotting. It helps assess bleeding risks or identify clotting disorders.
["Factor VII activity helps diagnose bleeding or clotting problems, especially in conditions affecting blood’s ability to clot properly."]
Key facts at a glance
- LOINC
- 49870-9
- Short code
- Fact VII Ag Act/Nor PPP IA
- Synonyms
- Fact VII Ag Act/Nor PPP IA
- Category
- chemistry
- Sample
- plasma
- Container
- Lavender-top (EDTA) or Green-top (Heparin)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- ia
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Matters
Factor VII is part of the intrinsic and extrinsic pathways that trigger blood clotting. Low levels can increase bleeding risk, while high levels may suggest certain clotting disorders. This test is often used in patients with inherited bleeding disorders, after trauma, or before surgeries.
When You Might Need This Test
Your doctor may order this test if you have symptoms like excessive bruising, prolonged bleeding from cuts, or if you’re scheduled for surgery. It’s also used in patients with liver disease, because the liver produces Factor VII.
What to Expect Before the Test
No special preparation is usually needed, but you may be asked to avoid certain medications (like blood thinners) for a few days before testing. Your doctor will provide specific instructions if applicable.
What Happens During the Test
A blood sample is drawn from a vein, typically in your arm. The sample is sent to a lab for testing. The process takes about 15 minutes, and you may feel a slight pinch or discomfort during the draw.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Low Factor VII activity can indicate bleeding disorders, liver disease, or vitamin K deficiency. High levels may be seen in certain clotting disorders or after blood transfusions. This test helps guide treatment decisions, such as medication adjustments or further investigations.
Short name
Factor VII Activity
Frequently asked questions
What does a low Factor VII activity mean?
How is Factor VII activity tested?
Can Factor VII activity change over time?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy