Factor VII Activity (Prothrombin Complex Concentration)
This test measures the activity level of Factor VII, a protein involved in blood clotting. It helps assess bleeding disorders or clotting risks, especially after trauma, surgery, or certain medications.
["Factor VII activity helps evaluate bleeding tendencies or clotting efficiency in your blood."]
Key facts at a glance
- LOINC
- 96456-9
- Short code
- Fact VIII Act + Inhib Pnl PPP
- Synonyms
- Fact VIII Act + Inhib Pnl PPP
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- coag
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Your healthcare provider may order this test if you have symptoms of bleeding (like excessive bruising, nosebleeds, or heavy menstrual periods), if you’ve had recent surgery or trauma, or if you’re taking blood-thinning medications. It may also be used to monitor conditions like liver disease, where clotting factors are affected.
What Does the Test Involve?
A blood sample is taken from a vein in your arm. The sample is sent to a lab where it’s analyzed to measure Factor VII activity levels. Results are typically reported as a percentage of normal activity.
What Do Results Mean?
Low Factor VII activity may indicate bleeding disorders or liver problems, while high levels could suggest certain clotting disorders or medications affecting clotting. Your results will be compared to a reference range provided by your healthcare provider.
What Are Common Causes?
Conditions like liver disease, vitamin K deficiency, or certain medications (e.g., anticoagulants) can lower Factor VII activity. Rarely, genetic disorders may cause abnormal levels.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: Factor VII Activity plays a critical role in the blood clotting process. It works alongside other clotting factors to stop bleeding after injuries. Abnormal levels can lead to excessive bleeding (hemophilia-related) or increased clotting risks (thrombosis), depending on the cause.
Short name
Factor VII Activity
Frequently asked questions
How often should I expect this test?
What should I do if I have a high or low Factor VII activity result?
Can diet or supplements affect Factor VII activity?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy