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Factor VII Activity (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the activity level of Factor VII, a protein involved in blood clotting. It helps assess bleeding risks or clotting disorders.

Quick summary

["Factor VII activity helps diagnose bleeding disorders or evaluate clotting function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
10396-0
Short code
Fact VIII Gvn Vol
Synonyms
Fact VIII Gvn Vol
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you have symptoms of bleeding problems, such as excessive bruising, prolonged bleeding from cuts, or unexplained nosebleeds. It may also be used before surgery to check your risk of bleeding, or if you have conditions like liver disease that can affect clotting.

What to Expect Before the Test

No special preparation is needed. You may have a blood sample drawn from a vein in your arm. If you’re on blood-thinning medication, check with your doctor first.

How the Test Works

Blood is collected and tested for Factor VII activity using a method that measures its ability to help blood clot. Results are expressed as a percentage of normal activity levels.

What the Results Mean

Results below normal may indicate bleeding disorders or liver disease. Results above normal are less common but could suggest certain blood disorders or medications affecting clotting. Your doctor will interpret results in the context of your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Factor VII (FVII) Activity

Frequently asked questions

What Are Common Causes of Low Factor VII?
Low Factor VII activity can be caused by liver disease (since the liver produces clotting factors), certain medications (like warfarin), blood disorders (like hemophilia), or vitamin K deficiency. Rarely, genetic conditions may also affect Factor VII levels.
How Does Factor VII Activity Relate to Surgery?
Low Factor VII activity increases the risk of bleeding during surgery. Doctors may adjust medications or use clotting factors to prevent excessive bleeding before procedures.
Can Diet or Supplements Affect Factor VII?
Dietary factors like vitamin K (found in leafy greens) can influence clotting factors, but Factor VII itself is not directly affected by supplements unless there’s a known deficiency.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy