Factor XIII Activity (Serum or Plasma)
This test measures the activity level of Factor XIII, a protein involved in blood clotting and wound healing. It helps assess bleeding disorders or conditions affecting clotting.
["Factor XIII supports blood clotting and tissue repair; low levels may indicate bleeding risks or clotting disorders."]
Key facts at a glance
- LOINC
- 109852-4
- Short code
- Fact XIII Inhib Msmt PPP
- Synonyms
- Fact XIII Inhib Msmt PPP
- Category
- chemistry
- Sample
- plasma
- Container
- Lavender-top (EDTA) or Green-top (Heparin)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Does Factor XIII Do in Your Body?
Factor XIII plays a critical role in stabilizing blood clots and promoting tissue repair after injuries. It works alongside other clotting factors to ensure wounds heal properly and excessive bleeding stops. Low activity can lead to prolonged bleeding, while high activity may be associated with clotting disorders.
Why Might You Need This Test?
Your doctor may order this test if you have symptoms like excessive bleeding (e.g., nosebleeds, heavy menstrual periods, or bruising easily), prolonged wound healing, or if you’re undergoing surgery or a procedure. It can also help diagnose conditions like Factor XIII deficiency or evaluate blood disorders.
How Is the Test Performed?
A blood sample is drawn from a vein in your arm. The sample is sent to a lab where Factor XIII activity is measured using specialized techniques, such as enzymatic assays. No special preparation is needed, but fasting may be advised depending on your doctor’s instructions.
What Are Common Results and Their Meanings?
Results are reported as a percentage or ratio of normal activity levels. A result below normal may indicate a bleeding disorder or inherited clotting issue. A result above normal could suggest rare clotting abnormalities, though this is less common. Your doctor will interpret the result in the context of your symptoms and medical history.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Factor XIII deficiency is a rare genetic condition that can cause spontaneous bleeding, especially in muscles, joints, or internal organs. It may also lead to delayed wound healing. While less common, elevated Factor XIII activity can sometimes be linked to inflammatory conditions or certain medications. Always discuss results with your healthcare provider to determine the best next steps.
Short name
Factor XIII Activity
Frequently asked questions
What Causes Low Factor XIII Activity?
What Causes High Factor XIII Activity?
How Often Should I Get This Test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy