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Total Protein in Serum (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum. Proteins are essential for many bodily functions, including transporting nutrients, maintaining fluid balance, and supporting immune responses.

Quick summary

["Your blood protein levels help assess overall health, kidney function, and potential nutritional deficiencies."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
61267-1
Short code
False ragweed IgE/IgE total %
Synonyms
False ragweed IgE/IgE total %
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why It’s Done

Doctors may order a total protein test to check for conditions like malnutrition, kidney disease, liver problems, or certain immune disorders. It can also help monitor treatment progress for conditions affecting protein production or breakdown.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if your doctor specifies it. Bring any medications you’re currently taking, as some may affect results.

How the Test Works

A blood sample is drawn from a vein in your arm. The serum (liquid part after clotting) is then analyzed to determine the total protein concentration using standard laboratory methods.

Possible Results and Interpretation

Results are reported in grams per deciliter (g/dL). Low levels may indicate malnutrition, kidney disease, or liver problems, while high levels could suggest conditions like multiple myeloma, severe dehydration, or chronic inflammation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Protein

Frequently asked questions

What does a low total protein level mean?
Low total protein levels may signal underlying health issues, such as poor nutrient absorption, kidney dysfunction, or liver disease. Your doctor will review your symptoms and other test results to determine the cause and next steps.
What does a high total protein level mean?
Elevated protein levels can occur with conditions like dehydration, chronic inflammation, or certain cancers. Further testing may be needed to identify the exact cause, especially if symptoms like fatigue or swelling are present.
Can diet affect my protein test results?
Yes, your diet can influence protein levels. High-protein diets or certain medical conditions (like kidney disease) may temporarily alter results. Always follow your doctor’s instructions for test preparation to ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy