Skip to content

Total Serum/Plasma Cholesterol (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of cholesterol in your blood, including both the cholesterol bound to proteins and the free cholesterol. Cholesterol is a fatty substance your body needs to function, but high levels can increase your risk of heart disease.

Quick summary

["Your cholesterol levels help assess heart health and guide prevention strategies."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
2570-0
Short code
Fat Stl-mCnc
Synonyms
Fat Stl-mCnc
Category
chemistry
Sample
stool
Container
Clean container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 g
Stability
Refrigerated: 24h, Frozen: 7d
TAT
4–24 hours
Order
routine

Why This Test Matters

Cholesterol is a vital component of cell membranes and a precursor for hormones and bile acids. While your body produces some cholesterol naturally, you also absorb it from dietary sources like fats and oils. This test helps doctors monitor whether your cholesterol levels are within a healthy range to prevent potential cardiovascular risks.

What to Expect Before the Test

No special preparation is needed for this test. You may have a blood draw from a vein in your arm, which is quick and usually painless. If you’re on a blood thinner or have a history of bleeding disorders, let your healthcare provider know beforehand.

How the Test Works

Blood is collected and processed to separate the serum or plasma from blood cells. The cholesterol is then measured using a highly sensitive analytical method to determine its precise concentration.

What the Results Mean

Results are typically reported as a single number representing the total cholesterol level. While specific reference ranges vary by lab, high levels may signal a need for lifestyle changes, dietary adjustments, or medical interventions to lower cholesterol.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Cholesterol

Frequently asked questions

What does a high cholesterol level indicate?
High cholesterol levels can increase the risk of plaque buildup in your arteries, leading to conditions like atherosclerosis, heart attack, or stroke. Your doctor may recommend further testing or treatments if your results are elevated, especially if you have risk factors like high blood pressure, diabetes, or a family history of heart disease.
What does a low cholesterol level suggest?
Very low cholesterol levels may raise concerns about nutritional deficiencies or underlying health conditions, though this is less common. Your doctor would review your overall health and medical history to determine if further evaluation is needed.
Can diet affect cholesterol test results?
Yes, diet plays a significant role. Foods high in saturated fats and trans fats can raise cholesterol, while foods rich in fiber, fruits, vegetables, and healthy fats (like olive oil and nuts) may help lower it. Avoiding alcohol-heavy meals before testing can also help ensure accurate results.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy