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Folate in Plasma (Total)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of folate, a B vitamin essential for healthy cell growth and DNA production, in your blood plasma. Low levels may indicate poor nutrition or certain medical conditions.

Quick summary

["Folate helps prevent birth defects and supports red blood cell production; low levels may need attention."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
1385-4
Short code
FCA Fract 1h p 300 ug CLN PO Plas-mCnc
Synonyms
FCA Fract 1h p 300 ug CLN PO Plas-mCnc
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to check for folate deficiency, especially if you have symptoms like fatigue, weakness, or unusual bleeding. It’s also used in pregnancy to screen for neural tube defects in a baby. Folate is important for overall health, and low levels can affect how your body uses other vitamins, like B12.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if your doctor specifies it. Bring any medications or supplements you take regularly, as they could affect results. Avoid heavy meals or alcohol before the blood draw.

What Happens During the Test?

A healthcare provider will insert a small needle into a vein in your arm to draw blood. You may feel a slight pinch, but it usually doesn’t cause discomfort. The blood sample is then sent to a lab for testing.

What Are Possible Results?

Results are compared to a reference range, but exact values can vary by lab. Low folate levels may trigger further testing or dietary advice. High levels might not need immediate action unless linked to other health concerns.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Plasma Folate

Frequently asked questions

What Does It Mean If My Levels Are Low?
Low folate can cause anemia, neurological issues, or increased risk of pregnancy complications. It’s often linked to poor diet, alcohol use, or certain medications. Your doctor may recommend supplements or dietary changes to boost levels.
What If My Levels Are High?
High folate alone is less common but may indicate overconsumption of fortified foods or supplements. It’s usually not a cause for concern unless combined with other symptoms or conditions.
How Often Should I Get This Test?
Your doctor will determine frequency based on your health status. Folate levels may be checked periodically if you have risk factors like pregnancy, certain cancers, or chronic illnesses.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy