Skip to content

Folate in Plasma (Mass Concentration)

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of folate, a B vitamin essential for healthy cell growth and DNA repair, in your blood plasma.

Quick summary

["Folate helps prevent birth defects and supports red blood cell production."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
1387-0
Short code
FCA Fract 3h p 300 ug CLN PO Plas-mCnc
Synonyms
FCA Fract 3h p 300 ug CLN PO Plas-mCnc
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Ref low
80
Ref high
200
Critical range
20 N/A – 400 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84436
SNOMED
302346007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to check for folate deficiency, which can cause anemia, neurological issues, or increase the risk of certain cancers. It’s also used in pregnancy to screen for neural tube defects in a fetus or to monitor folate levels in people with conditions like alcoholism or malabsorption disorders.

What to Expect Before the Test

No special preparation is needed unless instructed. You may be asked to fast for 8–12 hours before the test if it involves drawing blood from a vein.

What Happens During the Test?

A healthcare provider will insert a small needle into your arm to draw blood into a tube. The process usually takes a few minutes, and you may feel a brief pinch. The blood is then sent to a lab for analysis.

What Are Possible Results?

Results are compared to a reference range specific to your age, sex, and health status. Low levels may indicate deficiency, while high levels could signal conditions like liver disease or certain medications.

Reference range

Adult: 80-200 ng/dLN/A

Specimen: plasma

Take your thyroid medication after the blood draw if applicable. No fasting required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Low folate levels can lead to anemia, fatigue, or cognitive issues. In pregnancy, deficiency is linked to birth defects. High levels may require further evaluation for underlying conditions like kidney disease or medication use. Always discuss results with your doctor for personalized guidance.

Short name

Plasma Folate Level

Frequently asked questions

What causes low folate levels?
Common causes include poor diet (low intake of leafy greens, fortified foods), alcohol use, certain medications (e.g., anticonvulsants), or conditions like celiac disease or Crohn’s disease that affect nutrient absorption.
What symptoms might I experience if my folate is low?
Symptoms may include fatigue, weakness, pale or yellowish skin, shortness of breath, or neurological issues like numbness or memory problems. Some people may not notice symptoms until deficiency is severe.
Can folate levels change with diet?
Yes, diet plays a major role. Foods rich in folate include spinach, lentils, beans, fortified cereals, and citrus fruits. If you suspect dietary deficiencies, your doctor may recommend dietary changes or supplements under supervision.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy