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FcγRIIIA Gene Variant (rs17444830) – Carrier Status

Published: August 9, 2026Updated: August 16, 2026

This test checks whether you carry a specific genetic variation in the FcγRIIIA gene, which influences how your immune system responds to certain antibodies.

Quick summary

["Understanding your genetic variant may help explain immune-related health risks or responses to treatments."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
101546-0
Short code
FCGR3A gene.p.158 Bld
Synonyms
FCGR3A gene.p.158 Bld
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Doctors may recommend this test if you have a family history of immune disorders, autoimmune conditions, or if you’re being evaluated for conditions like certain cancers, infections, or immune-related diseases. It can also be used in research or to assess immune function in specific contexts.

What the Test Measures

The test identifies whether you have the common genetic variant (rs17444830) in the FcγRIIIA gene, which affects how your immune cells recognize and respond to antibodies like IgG. This variant is linked to differences in immune reactivity.

Sample Collection and Preparation

A small amount of blood is drawn from your arm into a tube. This blood sample is then processed to isolate DNA for genetic analysis. No special preparation is needed, but avoid strenuous activity 24 hours before your test.

What to Expect During and After the Test

The blood draw takes about 5 minutes. You may feel a slight pinch, but it’s generally quick and mild. Afterward, you can resume normal activities. Rarely, bruising or mild discomfort may occur at the site.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Having this genetic variant may influence your immune system’s ability to fight infections or respond to treatments like monoclonal antibodies (e.g., for cancer or autoimmune diseases). Some studies suggest it could also affect vaccine responses. However, results alone don’t diagnose a condition—they’re used alongside clinical findings to guide care.

Short name

FcγRIIIA Gene Test

Frequently asked questions

What does a positive result mean?
A positive result means you carry the specific genetic variant in question. This doesn’t mean you have a disease, but it may help explain why you or a family member might have certain immune-related traits or responses to treatments.
Does this test affect my treatment plan?
Not always. Your doctor will use the results in combination with your medical history, symptoms, and other tests to decide if this variant impacts your care. Some treatments may be adjusted based on genetic factors, but this depends on the specific condition being treated.
How often should I get this test?
This test is typically done once, unless you’re part of a research study, monitoring a specific condition, or your doctor recommends follow-up due to family history or symptoms related to immune function.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy