Serum/plasma concentration of fentanyl and norfentanyl (qualitative/quantitative screening/confirmation)

Why This Test Is Done

Your healthcare provider may order this test if you’re suspected of using fentanyl or other opioids, especially if you’re experiencing symptoms like confusion, slowed breathing, or withdrawal. It’s also used in treatment programs to monitor compliance with opioid-free regimens or to screen for illicit drug use in certain settings.

What to Expect Before the Test

No special preparation is needed. You’ll provide a urine sample in a sterile container. If this is part of a routine screening, you may be asked to follow a clean-catch urine collection method to ensure accuracy.

What the Results Mean

Positive results indicate the presence of fentanyl or norfentanyl in your urine, suggesting recent opioid exposure. The exact meaning depends on clinical context, such as whether this is a screening or confirmation test. Always discuss results with your provider.

Common Causes of Positive Results

Positive results can occur from intentional use of fentanyl (prescription or illicit), accidental exposure, or ingestion of products containing these substances. False positives are rare but may occur with certain medications or medical conditions.